MOTS-c is a mitochondria-derived open reading frame peptide, a unique signaling peptide encoded by the mitochondrial 12S rRNA gene rather than nuclear DNA. It functions as a key metabolic regulator that can translocate from mitochondria into the cytoplasm and nucleus to modulate cellular stress response, energy balance and metabolic homeostasis. It activates AMPK signaling pathway, promotes glucose uptake, enhances insulin sensitivity and facilitates the browning of white adipose tissue in preclinical studies. Research also shows MOTS-c participates in the regulation of skeletal muscle metabolism, exercise adaptation, inflammatory response and age-related metabolic decline. It can suppress excessive oxidative stress and low-grade chronic inflammation, which are closely linked to metabolic syndrome. Structurally stable under proper lyophilized storage, this peptide is produced via Fmoc solid-phase peptide synthesis. Each batch is verified by HPLC for purity, mass spectrometry for identity confirmation, with strict control over endotoxin and residual impurities to guarantee batch-to-batch consistency. The lyophilized powder greatly reduces peptide degradation during transportation and long-term preservation. It is widely applied in cell culture experiments, rodent model studies, metabolic aging research and screening of combined peptide formulations. Many researchers combine MOTS-c with other metabolic peptides to explore synergistic effects on energy metabolism and body composition regulation. This product is intended exclusively for academic laboratory research and formulation exploration.