AOD9604, also named Anti-Obesity Drug 9604, is a synthetic 16-amino-acid hexadecapeptide derived from the C-terminal fragment of human growth hormone (hGH residues 177–191), with an additional tyrosine residue added at the N-terminus to improve molecular stability and resist proteolytic degradation. It was originally developed by researchers at Monash University, engineered to separate the lipid-regulating biological activities of full-length human growth hormone away from its growth-promoting and IGF-1 elevating effects.

Unlike intact human growth hormone, AOD9604 does not bind to the growth hormone receptor and will not trigger a rise in IGF-1 levels, which makes it a valuable research tool to investigate adipose tissue metabolism. In preclinical research, AOD9604 participates in lipid regulation mainly through β3-adrenergic receptor related signaling pathways. It can promote lipolysis to break down stored fat and suppress lipogenesis to reduce new fat accumulation in adipocyte models.

Beyond fat metabolism studies, published preclinical research also explores its potential activity on cartilage and muscle progenitor cells. Research data indicates that AOD9604 may stimulate the synthesis of proteoglycan and collagen in cartilage tissue, and support the differentiation of muscle precursor cells, providing research material for osteoarthritis and muscle tissue repair related laboratory studies.

Our AOD9604 peptide is manufactured under strict peptide synthesis and purification workflows. Crude peptide is purified via preparative high-performance liquid chromatography, followed by lyophilization to lock biological stability. Each batch is fully tested by HPLC for purity and mass spectrometry (MS) for molecular identity verification. COA documents including HPLC chromatogram and MS report are available for every production lot. The lyophilized powder form greatly reduces peptide degradation during transportation and long-term cold storage. Once reconstituted, the peptide solution should be stored at 2–8°C for short-term use or aliquoted and frozen at -20°C to prevent repeated thawing damage.