Adipotide, also known as FTPP (Fat-Targeted Proapoptotic Peptide), is a synthetic chimeric peptidomimetic composed of two functional peptide domains. The homing sequence CKGGRAKDC is capable of binding prohibitin receptors enriched on endothelial cells of white adipose tissue blood vessels, while the linked D-amino acid pro-apoptotic motif D(KLAKLAK)? can disrupt mitochondrial membrane and induce endothelial cell apoptosis after internalization. Unlike GLP?1 peptides that mainly suppress appetite, Adipotide exerts research effects by selectively damaging the blood vessels supplying white fat tissue, cutting off nutrient and oxygen supply to adipocytes and triggering adipose tissue atrophy and resorption. It is widely used in preclinical animal research for obesity, adipose vascular biology, targeted peptide delivery and lipid homeostasis mechanism studies.

This chimeric peptide is synthesized via solid-phase peptide synthesis and purified by multi-step reversed-phase HPLC to remove truncated peptide fragments, oxidation by-products and residual organic solvents. Each batch is supplied with complete COA documents, including HPLC purity test, MS molecular weight verification, moisture detection, residual solvent analysis, endotoxin and microbial limit testing to guarantee stable batch consistency. The lyophilized powder form effectively slows peptide degradation and hydrolysis, maintaining good stability during cross-border shipment and long-term laboratory storage. Suitable research applications include in vitro endothelial cell apoptosis assays, adipose tissue vascular signal pathway research, in vivo obese animal model evaluation and targeted peptide stability testing.