AICAR, also known as Acadesine or 5-Aminoimidazole-4-carboxamide ribonucleotide, is a well-known cell-permeable AMPK activator widely utilized in energy metabolism research. Once entering cells, AICAR converts into ZMP, an active metabolite that mimics AMP and activates AMP-activated protein kinase (AMPK). AMPK serves as a master energy sensor inside cells; its activation regulates multiple downstream signaling pathways to boost glucose uptake, enhance fatty acid oxidation, suppress lipid synthesis and modulate mitochondrial biogenesis. It is commonly adopted for in vitro cell experiments and animal model research covering glucose metabolism, insulin sensitivity, lipid regulation, mitochondrial function and exercise adaptive response studies.

This product is produced through rigorous chemical synthesis and refined by multi-step purification processes to eliminate related impurities and residual solvents. Each batch comes with complete COA documents, including HPLC purity detection, MS molecular weight verification, moisture test, residual solvent analysis and microbial limit testing, which guarantees stable quality across different batches. The crystalline powder form features low moisture absorption and outstanding chemical stability, suitable for long-distance international transport and long-term storage. It can be applied to multiple research projects, such as cellular glucose uptake assays, AMPK signal pathway exploration, in vivo metabolic model evaluation and compound stability research.