PE-22-28 is a peptide derived from spadin that acts on TREK-1 potassium channels, a pathway implicated in mood regulation and antidepressant mechanisms. Its channel-targeting profile supports research into fast-acting neuromodulation strategies in behavioral models. This product is a white lyophilized powder at verified purity in a sealed vial, with batch-specific documentation and flexible ordering for research teams. All shipping documentation is prepared in English, and parcels destined for most countries are sent with full tracking and delivery confirmation. In the rare event of transit issues, our after-sales team assists with claims and replacement arrangements to minimize disruption to your work.

Preclinical studies have highlighted PE-22-28's potential to modulate neuronal excitability by enhancing TREK-1 channel activity, which may contribute to rapid anxiolytic and antidepressant-like effects in rodent models of stress and depression. The peptide's high specificity for TREK-1 over other potassium channels reduces off-target effects, making it a promising tool for dissecting the role of these channels in affective disorders. Researchers utilizing PE-22-28 can benefit from its stability in lyophilized form, allowing for long-term storage under standard laboratory conditions without loss of biological activity. Detailed reconstitution protocols and recommended dilution ranges are provided with each batch to ensure consistent experimental outcomes. Additionally, our technical support team is available to assist with experimental design, troubleshooting, and interpretation of results, ensuring that research teams can maximize the utility of this peptide in their studies of neuromodulation and psychiatric pharmacology.