Adipotide, also named FTPP (Fat-Targeted Proapoptotic Peptide), is a unique synthetic chimeric peptidomimetic constructed with two functionally independent domains linked by a short glycine-glycine spacer. Its N-terminal region forms a cyclic homing peptide through disulfide bond, which can selectively recognize and bind prohibitin protein expressed on endothelial cell surface of blood vessels feeding white adipose tissue. Once anchored on target vascular endothelium, the C-terminal D-amino acid peptide segment will enter the cell and trigger mitochondrial membrane damage, initiating programmed endothelial cell apoptosis.

Different from conventional lipolytic peptides that directly act on adipocyte lipid metabolism, Adipotide exerts its biological effect through vascular ablation mechanism. It blocks oxygen and nutrient delivery to fat tissue by destroying the microvasculature of white fat, resulting in gradual atrophy and clearance of adipocytes. Preclinical research data revealed that this peptide could reduce visceral and subcutaneous fat mass in animal models while preserving lean tissue, making it a distinctive research tool for exploring adipose vascular biology and obesity intervention strategies.

Our Adipotide is manufactured via solid-phase peptide synthesis with rigorous cyclization and purification steps. Since the molecule contains cyclic disulfide bonds and D-amino acid fragments, the synthesis workflow demands precise control over coupling efficiency and oxidation reaction to avoid misfolded peptides and truncated impurities. Every batch is verified by mass spectrometry to confirm full sequence integrity, while HPLC chromatogram ensures high purity and low content of by-products. The lyophilized formulation stabilizes the complex chimeric structure and minimizes degradation during international shipment and long-term cold storage.

When handling this product in laboratory settings, users should pay extra attention to aqueous stability. After reconstitution, Adipotide solution is susceptible to oxidation of cysteine residues. It is recommended to split the reconstituted liquid into single-use aliquots immediately and store frozen. Prolonged exposure to room temperature or repeated thawing may break the disulfide ring and impair targeting bioactivity. Operators must follow standard laboratory safety protocols when weighing and preparing working solutions.