PNC?27 is a synthetic 32?amino?acid chimeric peptide, consisting of HDM?2 binding domain derived from p53 tumor suppressor protein and C?terminal cell?penetrating membrane residency domain. It targets membrane?bound HDM?2 (MDM2) overexpressed on cancer cell surface, triggering membrane pore formation and inducing necrotic death for target cancer cells, while showing minimal impact on normal cells in pre?clinical studies.

This peptide is widely applied in oncology laboratory research, including tumor cell selective cytotoxicity assays, p53?HDM2 protein?protein interaction research, membrane lysis mechanism exploration, multiple cancer cell line tests and in?vivo xenograft animal model experiments. It serves as a valuable tool for anticancer peptide mechanism study and pre?clinical exploratory projectspinnypepti....

Our PNC?27 peptide is produced by mature solid?phase peptide synthesis. Each batch is strictly verified by HPLC and mass spectrometry to confirm high purity and full?length correct sequence. COA document is available upon customer request. Lyophilized powder provides excellent stability for transportation and long?term preservation. Multiple packaging specifications are supported, ranging from small laboratory sample vials to bulk kilogram?level orders.