Reduced Glutathione (GSH, CAS 70-18-8) is a natural active tripeptide formed by glutamic acid, cysteine and glycine. As an important endogenous antioxidant substance in organisms, it is a high-quality biochemical raw material widely applied in cosmetics, food, dietary supplements and pharmaceutical intermediate industries.

Reduced Glutathione (GSH) is a native intracellular tripeptide distinguished by the free thiol group on cysteine residue. This reactive sulfhydryl moiety underpins its core biological function as cellular redox buffer. Unlike synthetic modified peptides, GSH exists naturally inside most eukaryotic cells and serves as a key research reference for oxidation?relevant biological processes. Its structure contains an unusual gamma peptide linkage between glutamic acid and cysteine, which grants partial resistance toward common peptidases.

Oxidation to disulfide?bonded GSSG represents the main degradation risk throughout production and storage. Manufacturing adopts inert?gas?protected processing to minimise contact with oxygen. Each batch is examined by HPLC to quantify residual oxidised glutathione impurities, while mass spectrometry confirms target molecular mass. Researchers utilise this substance for intracellular antioxidant mechanism studies, oxidative stress cell models, detoxification?related biochemical testing and thiol?dependent enzyme activity assays.

Oxygen and light rapidly consume active thiol groups. Keep original container tightly sealed to limit air access. Aqueous GSH solution oxidises very quickly; prepare stock solution immediately before experiments, do not store dissolved solution long?term. Divide solid material into small working aliquots to reduce repeated opening of the main container.